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br Materials and methods br Results br Discussion We demonst
2024-06-24
Materials and methods Results Discussion We demonstrate reduced angiogenic activity in NDRG1 overexpressing malignant glioma leading to reduced glioma growth. This antiangiogenic phenotype is paralleled by a significant upregulation of the antiangiogenic gene TNFSF15. TNFSF15 upregulation i
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While there is structural information on the core of
2024-06-24
While there is structural information on the core of the amyloid fibril, less is known about oligomer structure. There is evidence that the C-terminal of Aβ may form beta barrels in some oligomer species (Tay et al., 2013, Do et al., 2016), or may exist as loosely aggregated strands in other oligome
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It has been known for a
2024-06-24
It has been known for a while that oxygenation (the addition of oxygen) of Aβ can inhibit the formation of amyloids and diminish their cytotoxicity. Photo-oxygenation of Aβ started with fullerenes almost a decade ago by Toshima and co-workers. Later, porphyrins and polyoxometalates were used as well
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br Role of AMPK in inflammation
2024-06-24
Role of AMPK in inflammation signaling Pro-inflammatory cytokines, such as interleukin (IL)-6 and tumor necrosis factor-α (TNF-α), activate Ikβ kinase (IKKβ), which phosphorylates IκBα, triggering the degradation of proteasomal IκB. This liberates active nuclear factor kB (NF-kB) to translocate i
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Similarly compound was prepared from aldehyde d
2024-06-24
Similarly, lp-pla2 inhibitor 13 was prepared from aldehyde 8d by following similar procedures (Scheme 3). Condensation of 13 with 7b or 7e provided the corresponding amides 9j or 9k, which then went through O-debenzylation by BCl3 to deliver the final compounds 10j and 10k in 37% and 32% overall yi
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In this study for the first instant we report the
2024-06-24
In this study, for the first instant we report the characterization, production and in silico structural analysis of BADH1 gene in B. haloduranss SMBPL06 isolated from the salt pan. Moreover, the sequence analysis of betaine aldehyde dehydrogenase from B. haloduranss SMBPL06 displayed several base s
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In conclusion we have shown that mGlu receptors negatively r
2024-06-24
In conclusion, we have shown that mGlu7 receptors negatively regulate α1-adrenergic receptor signalling in heterologous expression systems, colony stimulating factor 1 receptor tissue and living animals. This interaction might represent a protective mechanism aimed at restraining an excessive activ
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ap-1 transcription factor Whether similar mechanisms play a
2024-06-24
Whether similar mechanisms play a role in adiponectin signal transduction and whether additional proteins are recruited to adiponectin receptors via APPL1 has not been analysed so far. Although it has been clearly established that APPL1 is a downstream adaptor protein in adiponectin signal transduct
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Balaglitazone Cofilin is an additional actin severing
2024-06-24
Cofilin is an additional Balaglitazone severing protein present in sperm cells that undergo phosphorylation/inactivation on serine 3 by Lim kinases (LIMK) and by Tes kinases (TESK) [48]. LIMK can be activated by several pathways, including one through the Rho/ROCK/LIMK cascade [49], [50], [51]. Ano
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On another hand pyrazoles are
2024-06-24
On another hand, pyrazoles, are widely found as the core structure in a large variety of compounds of great biological and pharmaceutical value exhibiting anti-HCV [11], antitumor [12], cytotoxic[13], and antioxidant activities [14]. Finally, 1,2,3-triazoles have attracted the interest of medicinal
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Based on the observation that antipsychotic drugs increase H
2024-06-24
Based on the observation that antipsychotic drugs increase 5-HT1A–D2 heteromerization level (Łukasiewicz et al., 2016), we set out to compare the effect of paroxetine to that of risperidone. Paroxetine, a potent SSRI, is very effective in the treatment of depression and anxiety disorders, e.g., gene
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Although CP has been an important research subject in
2024-06-24
Although CP has been an important research subject in the field of antigen processing and presentation, the mechanisms of presentation of intracellular Lonidamine by MHC II received considerably less attention. Interestingly, pioneering work by the Münz laboratory has pointed to an involvement of au
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As shown in B the recombinant human LOX nM showed
2024-06-22
As shown in B, the recombinant human 15-LOX-1 (30nM) showed a time-dependent increase in fluorescent signal, and signal development was almost completed within 20min in the presence of 50μM arachidonic pdgfr inhibitor and 5μM DHR. For both purified enzyme and cell lysates, the enzyme activities dis
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br Materials and methods br
2024-06-22
Materials and methods Results Discussion The current treatment modalities for colorectal cancer are hampered by various issues such as high acquired resistance, long-term complication with potential of cancer recurrence, severe side-effects and poor therapeutic index [50], [51], [52]. Compl
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The elevated levels of intracellular antioxidant such as red
2024-06-22
The elevated levels of intracellular antioxidant such as reduced glutathione (GSH) are normally oberserved is various tumor 1,2-Dilauroyl-sn-glycerol which confers the chemoresistant to chemotherapy [59]. Therefore, the induction of oxidative stress via elevation of intracellular ROS and dimunition
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